International Journal of General Medicine (Jan 2022)

A Novel Ferroptosis-Related lncRNA Signature for Prognosis Prediction in Patients with Papillary Renal Cell Carcinoma

  • Dang R,
  • Jin M,
  • Nan J,
  • Jiang X,
  • He Z,
  • Su F,
  • Li D

Journal volume & issue
Vol. Volume 15
pp. 207 – 222

Abstract

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Ruijie Dang,1,* Meiling Jin,2,* Jingzhu Nan,3 Xuege Jiang,4 Zheng He,5 Fang Su,6 Diangeng Li7 1Department of Oncology, The First Medical Centre, Chinese PLA General Hospital, Beijing, 100853, People’s Republic of China; 2Department of Nephrology, Beijing-Chaoyang Hospital, Capital Medical University, Beijing, 100020, People’s Republic of China; 3Department of Clinical Laboratory, the First Medical Centre, Chinese PLA General Hospital, Beijing, 100853, People’s Republic of China; 4Respiratory Diseases Department, Second Medical Center of PLA General Hospital, Beijing, 100853, People’s Republic of China; 5Department of Clinical Laboratory, Chinese PLA General Hospital, Beijing, 100853, People’s Republic of China; 6Aeronautical Physiological Identification Training Laboratory, Air Force Medical Center, PLA, Beijing, 100142, People’s Republic of China; 7Department of Scientific Research, Beijing-Chaoyang Hospital, Capital Medical University, Beijing, 100020, People’s Republic of China*These authors contributed equally to this workCorrespondence: Diangeng LiDepartment of Scientific Research, Beijing-Chaoyang Hospital, Capital Medical University, Beijing, 100020, People’s Republic of ChinaTel/Fax +86-10-85231049Email [email protected]: Papillary renal cell carcinoma (PRCC) is a common renal cell carcinoma. Recent studies have reported that ferroptosis is involved in the occurrence and development of tumors. Long non-coding RNAs can be used as independent biomarkers for the diagnosis and prognosis of a variety of tumors.Methods: Gene expression profile and clinical information of patients with PRCC were obtained from The Cancer Genome Atlas (TCGA) database. Lasso penalized Cox regression and univariate Cox regression analysis were utilized for model construction. The Kaplan–Meier (K-M) and receiver operating characteristic (ROC) curves were plotted to validate the predictive effect of the prognostic signature. Immune cell infiltration and immune function were compared between the high-risk and low-risk groups. Chemotherapy sensitivity analysis was also performed.Results: We constructed a prognostic signature consisting of 15 ferroptosis-related lncRNAs. The K-M curves validated the fine predictive accuracy of the prognostic signature (p

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