Clinical, Cosmetic and Investigational Dermatology (Aug 2019)
Six critical questions for DNA repair enzymes in skincare products: a review in dialog
Abstract
Daniel B Yarosh,1 Amanda Rosenthal,2,3 Ronald Moy31Daniel B Yarosh Inc., Merrick, NY, USA; 2Department of Dermatology and Cutaneous Surgery, University of Miami, Miami, FL, USA; 3Research Department, Moy-Fincher-Chipps Facial Plastics/Dermatology, Beverly Hills, CA, USACorrespondence: Daniel B YaroshDaniel B Yarosh Inc., 2915 Shore Drive, Merrick, NY 11566, USATel +1 516 510 7100Email [email protected]: Concerns over existing sunscreen filters have reinforced the need to examine supplemental sun protection or repair of sun damage. Technology to enhance DNA repair has been available in skincare and sunscreen products for several decades, but skepticism and lack of familiarity with the supporting data remain prevalent. Here, we address six of the main questions raised by medical professionals regarding the efficacy of DNA repair enzymes in sun protection. These include the mode of delivery and mechanism of action, the effect on cellular responses and the amelioration of pre-cancers, cancers and photoaging. The conclusions are that topical DNA repair enzymes do enhance removal of DNA damage and reduce the appearance of new actinic keratoses as well as increase regression of existing lesions. Support for prevention of photoaging and skin cancer is significant but could be strengthened or disproven with additional research.Keywords: DNA repair, skin cancer, T4 endonuclease V, photolyase, UV endonuclease, actinic keratosis
