Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif

Jesse B. Yoder; Manu Ben-Johny; Federica Farinelli; Lakshmi Srinivasan; Sophie R. Shoemaker; Gordon F. Tomaselli; Sandra B. Gabelli; L. Mario Amzel

doi:10.1038/s41467-019-09570-7

Nature Communications (Apr 2019)

Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif

Jesse B. Yoder,
Manu Ben-Johny,
Federica Farinelli,
Lakshmi Srinivasan,
Sophie R. Shoemaker,
Gordon F. Tomaselli,
Sandra B. Gabelli,
L. Mario Amzel

Affiliations

Jesse B. Yoder: Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine
Manu Ben-Johny: Department of Physiology and Cellular Biophysics, Columbia University
Federica Farinelli: Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine
Lakshmi Srinivasan: Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine
Sophie R. Shoemaker: Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine
Gordon F. Tomaselli: Division of Cardiology, Department of Medicine, Albert Einstein College of Medicine
Sandra B. Gabelli: Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine
L. Mario Amzel: Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine

DOI: https://doi.org/10.1038/s41467-019-09570-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

Read online

Skeletal muscle voltage-gated Na+ channel (NaV1.4) activity is subject to calmodulin (CaM) mediated Ca2 +-dependent inactivation while cardiac NaV1.5 is not. Here authors use structural biology, binding and electrophysiology to parse the Ca2 +-dependent changes of CaM when bound to the NaV1.4.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal