No Evidence of Ntwetwe Virus Infections in Children Presenting to Kiboga Hospital, Uganda

Arthur W. D. Edridge; Nathalie van den Brekel; Philly Mukungu; Rachael Nakayima; Samuel Bbosa; Peter Isagara; Michael van Boele Hensbroek; Lia van der Hoek; John Kayiwa; Julius J. Lutwama; Richard Idro

doi:10.3390/tropicalmed8010021

Tropical Medicine and Infectious Disease (Dec 2022)

No Evidence of Ntwetwe Virus Infections in Children Presenting to Kiboga Hospital, Uganda

Arthur W. D. Edridge,
Nathalie van den Brekel,
Philly Mukungu,
Rachael Nakayima,
Samuel Bbosa,
Peter Isagara,
Michael van Boele Hensbroek,
Lia van der Hoek,
John Kayiwa,
Julius J. Lutwama,
Richard Idro

Affiliations

Arthur W. D. Edridge: Center for Global Child Health, Emma’s Children Hospital, Amsterdam UMC, Location AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
Nathalie van den Brekel: Center for Global Child Health, Emma’s Children Hospital, Amsterdam UMC, Location AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
Philly Mukungu: Kiboga District Hospital, Kiboga P.O. Box 17, Uganda
Rachael Nakayima: Kiboga District Hospital, Kiboga P.O. Box 17, Uganda
Samuel Bbosa: Kiboga District Hospital, Kiboga P.O. Box 17, Uganda
Peter Isagara: Kiboga District Hospital, Kiboga P.O. Box 17, Uganda
Michael van Boele Hensbroek: Center for Global Child Health, Emma’s Children Hospital, Amsterdam UMC, Location AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
Lia van der Hoek: Virus Discovery Group, Laboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, Location AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
John Kayiwa: Department of Arbovirology, Ugandan Virus Research Institute, Entebbe P.O. Box 49, Uganda
Julius J. Lutwama: Department of Arbovirology, Ugandan Virus Research Institute, Entebbe P.O. Box 49, Uganda
Richard Idro: Department of Paediatrics, Mulago Hospital, College of Health Science, Makerere University, Kampala P.O. Box 7051, Uganda

DOI: https://doi.org/10.3390/tropicalmed8010021
Journal volume & issue: Vol. 8, no. 1
p. 21

Abstract

Read online

We investigated whether Ntwetwe virus—a novel orthobunyavirus discovered in a Ugandan girl with a fatal encephalopathy—was a common reason for hospital admission for children to Kiboga hospital, Uganda. A case–control was conducted between September 2019 and September 2020, including cases with severe neurological disease and mild febrile illness, matched to a healthy control without fever. Among 143 subjects, no cases with an acute infection were identified. This result suggests that Ntwetwe virus does not cause a major burden of disease amongst children presenting to Kiboga hospital during the study period.

Published in Tropical Medicine and Infectious Disease

ISSN: 2414-6366 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine
Website: http://www.mdpi.com/journal/tropicalmed

About the journal

Abstract

Keywords