Stroke subtype-dependent synapse elimination by reactive gliosis in mice

Xiaojing Shi; Longlong Luo; Jixian Wang; Hui Shen; Yongfang Li; Muyassar Mamtilahun; Chang Liu; Rubing Shi; Joon-Hyuk Lee; Hengli Tian; Zhijun Zhang; Yongting Wang; Won-Suk Chung; Yaohui Tang; Guo-Yuan Yang

doi:10.1038/s41467-021-27248-x

Nature Communications (Nov 2021)

Stroke subtype-dependent synapse elimination by reactive gliosis in mice

Xiaojing Shi,
Longlong Luo,
Jixian Wang,
Hui Shen,
Yongfang Li,
Muyassar Mamtilahun,
Chang Liu,
Rubing Shi,
Joon-Hyuk Lee,
Hengli Tian,
Zhijun Zhang,
Yongting Wang,
Won-Suk Chung,
Yaohui Tang,
Guo-Yuan Yang

Affiliations

Xiaojing Shi: School of Biomedical Engineering and Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University
Longlong Luo: School of Biomedical Engineering and Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University
Jixian Wang: Department of Rehabilitation, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University
Hui Shen: School of Biomedical Engineering and Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University
Yongfang Li: Department of Rehabilitation, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University
Muyassar Mamtilahun: School of Biomedical Engineering and Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University
Chang Liu: School of Biomedical Engineering and Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University
Rubing Shi: School of Biomedical Engineering and Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University
Joon-Hyuk Lee: Department of Biological Sciences, Korea Advanced Institute of Science and Technology
Hengli Tian: School of Biomedical Engineering and Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University
Zhijun Zhang: School of Biomedical Engineering and Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University
Yongting Wang: School of Biomedical Engineering and Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University
Won-Suk Chung: Department of Biological Sciences, Korea Advanced Institute of Science and Technology
Yaohui Tang: School of Biomedical Engineering and Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University
Guo-Yuan Yang: School of Biomedical Engineering and Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University

DOI: https://doi.org/10.1038/s41467-021-27248-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 19

Abstract

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Microglia and astrocytes clear neuronal debris after stroke, whether glia remain phagocytic and cause synapse loss at the subacute stage remains unknown. Here, the authors show in a murine model of ischemic stroke that inhibition of phagocytosis by MEGF10 and MERTK deletion in microglia and astrocytes attenuated damage and improved neurological outcomes by preventing synapse loss.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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