Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries

Yixiao Gong; Charalampos Lazaris; Theodore Sakellaropoulos; Aurelie Lozano; Prabhanjan Kambadur; Panagiotis Ntziachristos; Iannis Aifantis; Aristotelis Tsirigos

doi:10.1038/s41467-018-03017-1

Nature Communications (Feb 2018)

Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries

Yixiao Gong,
Charalampos Lazaris,
Theodore Sakellaropoulos,
Aurelie Lozano,
Prabhanjan Kambadur,
Panagiotis Ntziachristos,
Iannis Aifantis,
Aristotelis Tsirigos

Affiliations

Yixiao Gong: Department of Pathology, NYU School of Medicine
Charalampos Lazaris: Department of Pathology, NYU School of Medicine
Theodore Sakellaropoulos: School of Mechanical Engineering, National Technical University of Athens
Aurelie Lozano: Center for Computational and Statistical Learning, IBM T.J. Watson Research Center
Prabhanjan Kambadur: Bloomberg LP
Panagiotis Ntziachristos: Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University
Iannis Aifantis: Department of Pathology, NYU School of Medicine
Aristotelis Tsirigos: Department of Pathology, NYU School of Medicine

DOI: https://doi.org/10.1038/s41467-018-03017-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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Topologically associating domains (TADs) detected by Hi-C technologies are megabase-scale areas of highly interacting chromatin. Here Gong, Lazaris et al. develop a computational approach to improve the reproducibility of Hi-C contact matrices and stratify TAD boundaries based on their insulating strength.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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