Data in Brief (Jun 2018)

Data of the effects of acetone fraction from Sechium edule (Jacq.) S.w. edible roots in the kidney of endothelial dysfunction induced mice

  • Celeste Trejo-Moreno,
  • Gabriela Castro-Martínez,
  • Marisol Méndez-Martínez,
  • Jesús Enrique Jiménez-Ferrer,
  • José Pedraza-Chaverri,
  • Gerardo Arrellín,
  • Alejandro Zamilpa-Álvarez,
  • Omar Noel Medina-Campos,
  • Galia Lombardo-Earl,
  • Gerardo Joel Barrita-Cruz,
  • Beatriz Hernández,
  • Christian Carlos Ramírez,
  • María Angélica Santana,
  • Gladis Fragoso,
  • Gabriela Rosas

Journal volume & issue
Vol. 18
pp. 448 – 453

Abstract

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Endothelial dysfunction induced by Angiotensin II (AG II) plays an important role in the pathogenesis of hypertension and is accompanied by a prooxidative condition, which in turn induces an inflammatory state, vascular remodeling, and tissue damage including the kidney (Schmitt and Dirsch, 2009) [1]. New drugs that can control several of these pathologies are required. Sechium edule has been reported to possess antioxidant, anti-inflammatory and antihypertensive activity (Ibarra-Alvarado et al., 2010) [2]. This paper contains data complementary to those published in Journal of Ethnopharmacology (Moreno et al., 2018) [3], evaluating the effect in kidney of hypertensive mice of the acetone fraction from S. edule to control de pro-oxidative state, reduction of the inflammatory adhesion molecule (ICAM) and recruitment of inflammatory cells.