Nature Communications (Feb 2020)
TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages
- Daria Bottai,
- Wafa Frigui,
- Fadel Sayes,
- Mariagrazia Di Luca,
- Dalila Spadoni,
- Alexandre Pawlik,
- Marina Zoppo,
- Mickael Orgeur,
- Varun Khanna,
- David Hardy,
- Sophie Mangenot,
- Valerie Barbe,
- Claudine Medigue,
- Laurence Ma,
- Christiane Bouchier,
- Arianna Tavanti,
- Gerald Larrouy-Maumus,
- Roland Brosch
Affiliations
- Daria Bottai
- Department of Biology, University of Pisa
- Wafa Frigui
- Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics
- Fadel Sayes
- Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics
- Mariagrazia Di Luca
- Department of Biology, University of Pisa
- Dalila Spadoni
- Department of Biology, University of Pisa
- Alexandre Pawlik
- Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics
- Marina Zoppo
- Department of Biology, University of Pisa
- Mickael Orgeur
- Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics
- Varun Khanna
- Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics
- David Hardy
- Institut Pasteur, Experimental Neuropathology Unit
- Sophie Mangenot
- Génomique Métabolique, Genoscope, Institut de biologie François Jacob, Commissariat à l’Energie Atomique (CEA), CNRS, Université Evry, Université Paris-Saclay
- Valerie Barbe
- Génomique Métabolique, Genoscope, Institut de biologie François Jacob, Commissariat à l’Energie Atomique (CEA), CNRS, Université Evry, Université Paris-Saclay
- Claudine Medigue
- LABGeM, Génomique Métabolique, Genoscope, Institut François Jacob, CEA, CNRS, Univ Evry, Université Paris-Saclay
- Laurence Ma
- Institut Pasteur, Plate-forme génomique, Pasteur Genopole Ile de France
- Christiane Bouchier
- Institut Pasteur, Plate-forme génomique, Pasteur Genopole Ile de France
- Arianna Tavanti
- Department of Biology, University of Pisa
- Gerald Larrouy-Maumus
- MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Faculty of Natural Sciences, Imperial College London
- Roland Brosch
- Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics
- DOI
- https://doi.org/10.1038/s41467-020-14508-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Mycobacterium tuberculosis (Mtb) modern strains emerged from a common progenitor after the loss of Mtb-specific deletion 1 region (TbD1). Here, the authors show that deletion of TbD1 correlates with enhanced Mtb virulence in animal models, mirroring the development of hypoxic granulomas in human disease progression.
