Molecules
(Sep 2022)
Brasesquilignan A–E, Five New Furofurans Lignans from <i>Selaginella braunii</i> Baker
Fei Cheng,
Jianping Wu,
Yan Zhang,
Yuyan Wang,
Guihua Li,
Hongliang Zeng,
Xiaoai He,
Guiming Deng,
Jianbin Tan,
Hongping Long,
Puhua Zeng,
Yiheng Liu,
Gangzhi Zhu,
Zuhui Chen,
Kangping Xu
Affiliations
Fei Cheng
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China
Jianping Wu
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China
Yan Zhang
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China
Yuyan Wang
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China
Guihua Li
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China
Hongliang Zeng
Institute of Chinese MateriaMedica, Hunan Academy of Chinese Medicine, Changsha 410013, China
Xiaoai He
Haikou People’s Hospital and Central South University, Xiangya School of Medicine Affiliated Haikou Hospital, Haikou 570208, China
Guiming Deng
The First Hospital of Hunan University of Chinese Medicine, Changsha 410007, China
Jianbin Tan
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China
Hongping Long
The First Hospital of Hunan University of Chinese Medicine, Changsha 410007, China
Puhua Zeng
Institute of Chinese MateriaMedica, Hunan Academy of Chinese Medicine, Changsha 410013, China
Yiheng Liu
Haikou People’s Hospital and Central South University, Xiangya School of Medicine Affiliated Haikou Hospital, Haikou 570208, China
Gangzhi Zhu
Haikou People’s Hospital and Central South University, Xiangya School of Medicine Affiliated Haikou Hospital, Haikou 570208, China
Zuhui Chen
Hunan QingYa Health Service Limited Company, Changsha 410083, China
Kangping Xu
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China
DOI
https://doi.org/10.3390/molecules27196349
Journal volume & issue
Vol. 27,
no. 19
Abstract
Read online
Five new furofurans lignans, Brasesquilignan A–E (1–5), were isolated from the aqueous ethanol extract of Selaginella braunii Baker. Their structures were elucidated by extensive analysis of NMR and HRESIMS data. Their absolute configurations were determined by CD spectra, enzymatic hydrolysis, and GCMS analysis. Furthermore, all compounds were evaluated for anti-proliferative activities against various human cancer cellsin vitro. Compounds 2 and 3 exhibited weak inhibitorypotency against five human cancer cells.
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