Immunotherapy and Cancer: The Multi-Omics Perspective

Clelia Donisi; Andrea Pretta; Valeria Pusceddu; Pina Ziranu; Eleonora Lai; Marco Puzzoni; Stefano Mariani; Elena Massa; Clelia Madeddu; Mario Scartozzi

doi:10.3390/ijms25063563

International Journal of Molecular Sciences (Mar 2024)

Immunotherapy and Cancer: The Multi-Omics Perspective

Clelia Donisi,
Andrea Pretta,
Valeria Pusceddu,
Pina Ziranu,
Eleonora Lai,
Marco Puzzoni,
Stefano Mariani,
Elena Massa,
Clelia Madeddu,
Mario Scartozzi

Affiliations

Clelia Donisi: Medical Oncology Unit, Department of Medical Sciences and Public Health, “Azienda Ospedaliero Universitaria” of Cagliari, University of Cagliari, 09042 Cagliari, Italy
Andrea Pretta: Medical Oncology Unit, Department of Medical Sciences and Public Health, “Azienda Ospedaliero Universitaria” of Cagliari, University of Cagliari, 09042 Cagliari, Italy
Valeria Pusceddu: Medical Oncology Unit, Department of Medical Sciences and Public Health, “Azienda Ospedaliero Universitaria” of Cagliari, University of Cagliari, 09042 Cagliari, Italy
Pina Ziranu: Medical Oncology Unit, Department of Medical Sciences and Public Health, “Azienda Ospedaliero Universitaria” of Cagliari, University of Cagliari, 09042 Cagliari, Italy
Eleonora Lai: Medical Oncology Unit, Department of Medical Sciences and Public Health, “Azienda Ospedaliero Universitaria” of Cagliari, University of Cagliari, 09042 Cagliari, Italy
Marco Puzzoni: Medical Oncology Unit, Department of Medical Sciences and Public Health, “Azienda Ospedaliero Universitaria” of Cagliari, University of Cagliari, 09042 Cagliari, Italy
Stefano Mariani: Medical Oncology Unit, Department of Medical Sciences and Public Health, “Azienda Ospedaliero Universitaria” of Cagliari, University of Cagliari, 09042 Cagliari, Italy
Elena Massa: Medical Oncology Unit, Department of Medical Sciences and Public Health, “Azienda Ospedaliero Universitaria” of Cagliari, University of Cagliari, 09042 Cagliari, Italy
Clelia Madeddu: Medical Oncology Unit, Department of Medical Sciences and Public Health, “Azienda Ospedaliero Universitaria” of Cagliari, University of Cagliari, 09042 Cagliari, Italy
Mario Scartozzi: Medical Oncology Unit, Department of Medical Sciences and Public Health, “Azienda Ospedaliero Universitaria” of Cagliari, University of Cagliari, 09042 Cagliari, Italy

DOI: https://doi.org/10.3390/ijms25063563
Journal volume & issue: Vol. 25, no. 6
p. 3563

Abstract

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Immunotherapies have revolutionized cancer treatment approaches. Because not all patients respond positively to immune therapeutic agents, it represents a challenge for scientists who strive to understand the mechanisms behind such resistance. In-depth exploration of tumor biology, using novel technologies such as omics science, can help decode the role of the tumor immune microenvironment (TIME) in producing a response to the immune blockade strategies. It can also help to identify biomarkers for patient stratification and personalized treatment. This review aims to explore these new models and highlight their possible pivotal role in changing clinical practice.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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