In vivo selection of a multidrug-resistant Aeromonas salmonicida during medicinal leech therapy

E. Ruppé; A. Cherkaoui; N. Wagner; G.C. La Scala; J.-Y. Beaulieu; M. Girard; J. Frey; V. Lazarevic; J. Schrenzel

New Microbes and New Infections (Jan 2018)

In vivo selection of a multidrug-resistant Aeromonas salmonicida during medicinal leech therapy

E. Ruppé,
A. Cherkaoui,
N. Wagner,
G.C. La Scala,
J.-Y. Beaulieu,
M. Girard,
J. Frey,
V. Lazarevic,
J. Schrenzel

Affiliations

E. Ruppé: Genomic Research Laboratory, Division of Infectious Diseases, Switzerland; Corresponding author. E. Ruppe, Genomic Research Laboratory, Division of Infectious Diseases, Geneva University Hospitals, 4 rue Gabrielle-Perret-Gentil, CH-1205 Geneva, Switzerland.
A. Cherkaoui: Bacteriology Laboratory, Division of Laboratory Medicine, Department of Genetics and Laboratory Medicine, Switzerland
N. Wagner: Pediatric Infectious Diseases, Department of Pediatrics, Switzerland
G.C. La Scala: Division of Pediatric Surgery, Department of Pediatrics, Switzerland
J.-Y. Beaulieu: Hand Surgery Unit, Division of Orthopedic Surgery, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
M. Girard: Genomic Research Laboratory, Division of Infectious Diseases, Switzerland
J. Frey: Institute of Veterinary Bacteriology, University of Bern, Bern, Switzerland
V. Lazarevic: Genomic Research Laboratory, Division of Infectious Diseases, Switzerland
J. Schrenzel: Genomic Research Laboratory, Division of Infectious Diseases, Switzerland; Bacteriology Laboratory, Division of Laboratory Medicine, Department of Genetics and Laboratory Medicine, Switzerland

Journal volume & issue: Vol. 21
pp. 23 – 27

Abstract

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We report the selection in a 15-year-old boy of a multidrug-resistant, extended-spectrum β-lactamase (ESBL)-producing Aeromonas salmonicida after medicinal leech therapy that required an antibiotic prophylaxis based on piperacillin/tazobactam and cotrimoxazole. Whole genome sequencing of the strain indeed revealed 13 antibiotic resistance genes, including the ESBL CTX-M-3 and the unusual β-lactamase SCO-1. Keywords: Aeromonas salmonicida, medicinal leech therapy, multidrug resistance, whole genome sequencing

Published in New Microbes and New Infections

ISSN: 2052-2975 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: https://www.sciencedirect.com/journal/new-microbes-and-new-infections

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