The Influence Of Lean Body Mass In Pd Patients

Abstract

Nutrition is one of the important issues and edema will overestimate the real body weight among dialysis patients. Lean body mass might reflect the real nutrition status. Creatinine is the product of muscle metabolism, creatinine generation can reflect the lean body mass (LBM). In peritoneal dialysis (PD) patients, creatinine generation could be evaluated by routine clearance measurement. This study will investigate the relationship among LBM, patient survival and PD technique therapy. Between 2002 and 2003, a total 115 patients who underwent PD for more than 3 months were enrolled in this study. Follow up ended in Dec. 2011. These patients were categorized into two groups according the median value of lean body mass to body weight (LBM/BW %) evaluated at first month. Age, sex, serum creatinine, albumin, and normalized protein catabolic rate (nPCR) were the independent determinants for LBM/BW%. The patient survival (68 vs 94 months ) and technique survival (55 vs 65 months) were longer in the higher LBM/BW%. Besides, peritonitis incidence, hospitalization episodes and hospitalization stay duration were lower in the higher LBM/BW% groups. The LBM/BW% is also the independent determinant for technique and patient survival after adjustment of age, diabetes, sex. In conclusion, initial LBM/BM% can predict PD patients and technique survival. Since the LBM/BW% is easily obtained in the routine PD clearance measurement and can reflect the real nutrition status, this parameter could be used extendedly to predict PD outcomes.