Risk Factors For Nosocomial Pan Drug Resistant Acinetobacter Baumannii Infections

Abstract

Aim: Acinetobacter baumannii is an important nosocomial pathogen. The purpose of this study was to identify risk factors and mortality of nosocomial infections caused by pan drug resistant (PDR) Acinetobacter baumannii and to characterize their effects on mortality.Patients and Methods: This study was performed at the Afyonkarahisar Helath Science University, Faculty of Medicine. Nosocomial infections were defined accor-ding to the American Center for Disease Control (CDC). Patients with nosocomial infections caused by Acinetobacter baumannii were included in the study. Patients identified as PDR Acinetobacter baumannii and non-PDR Acinetobacter baumannii infection were com-pared in terms of risk factors.Results: Two different groups were constructed, one group consisting of 145 PDR and the other of 145 non-PDR Acinetobacter baumannii cases. Stay history in an internal intensive care unit (p=0.001), their duration of hospital stay (p=0.031), renal disease (p=0.003), mechanical ventilation (p=0.001), prior usage history of carbap-enem (p=0.001), presence of nosocomial pneumonia (p=0.001), were independent risk factors associated with PDR Acinetobacter baumannii infections. The mortality rate for the PDR group was 61.8% and it was 38.2% in the non-PDR group (p=0.008).Conclusion: PDR Acinetobacter baumannii infections are important nosocomial in-fections with a high mortality rate. Patients’ carbapenem usage, stay history in an internal intensive care unit, renal comorbid diseases, and a diagnosis of nosocomial pneumonia are important risk factors for PDR Acinetobacter baumannii infections. In nosocomial infections caused by PDR Acinetobacter baumannii, many risk factors were modifiable.

Keywords

• acinetobacter baumannii
• antibiyotik direnci
• antimikrobiyal tedavi
• acinetobacter baumannii
• antibiotic resistance
• antimicrobial therapy