A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer’s disease and gastrointestinal tract disorders

Emmanuel O. Adewuyi; Eleanor K. O’Brien; Dale R. Nyholt; Tenielle Porter; Simon M. Laws

doi:10.1038/s42003-022-03607-2

Communications Biology (Jul 2022)

A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer’s disease and gastrointestinal tract disorders

Emmanuel O. Adewuyi,
Eleanor K. O’Brien,
Dale R. Nyholt,
Tenielle Porter,
Simon M. Laws

Affiliations

Emmanuel O. Adewuyi: Centre for Precision Health, Edith Cowan University
Eleanor K. O’Brien: Centre for Precision Health, Edith Cowan University
Dale R. Nyholt: Centre for Genomics and Personalised Health, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology
Tenielle Porter: Centre for Precision Health, Edith Cowan University
Simon M. Laws: Centre for Precision Health, Edith Cowan University

DOI: https://doi.org/10.1038/s42003-022-03607-2
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 14

Abstract

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A cross-trait meta-analysis of several genome-wide association studies suggest that Alzheimer’s disease shares a common genetic basis (including 7 shared loci) and underlying biological pathways with gastrointestinal tract disorders.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal