Diagnostic Value of Cyclophilin A in Acute Ischemic Stroke

Abstract

Aim: The early diagnosis and treatment of patients presenting to the emergency department symptoms of stroke can significantly reduce mortality and morbidity rates associated with it. This study aimed to investigate the diagnostic value of serum yclophilin A levels in our study group who presented to the emergency department with symptoms of acute ischemic stroke.Materials and Methods: In total, 114 patients diagnosed with acute ischemic stroke between October 2013 and October 2014 and a control group of 66 healthy volunteers were included. Cyclophilin A levels in the patient and control groups were compared.Results: The median cyclophilin A levels in the patient and control groups measured at the time of presentation were 13.47 (11.97–17.92) ng/mL and 11.54 (8.48–16.22) ng/mL, respectively. These levels were significantly higher in the patient group than in the control group (p<0.05).Conclusion:Plasma cyclophilin A levels were significantly higher in the patient group than in the control group.

Keywords

• Acute ischemic stroke
• cyclophilin A
• emergency department