CSF Picture In Aneurysmal Subarachnoid Hemorrhage

Abstract

Objectives: The current study aims to observe the effect of thedisease pathology on the CSF picture at admission and how theindividual CSF determinants affect the patient outcome.Materials and Methods: A retrospective review of the levelsof CSF glucose, protein, white blood cell count and culture in661 cases of aneurysmal subarachnoid hemorrhage was donefrom the records of Thomas Jefferson University Hospital.Parameters were analyzed by student’s t test, p <0.05 is takenas significant.Results: Higher CSF glucose as well as CSF protein atadmission worsened the chances of a good outcome, althoughCSF glucose < 40mg/dl and CSF protein < 15mg/dl atadmission were associated with higher mortality. CSF whiteblood cell count of 3-5 /ml was associated with the bestoutcome, also culture negative cases had a better prognosis.Conclusions: All the CSF parameters studied gave the bestprognostic results in their median values. More elaborate andprospective studies may be considered to give us a clearerpicture.

Keywords

• Aneurysmal subarachnoid hemorrhage
• cerebrospinal fluid
• protein
• glucose
• white blood cell
• extended Glasgow outcome score.