Fecal microbiota transplantation: an update on the advances in the treatment of complex diseases

Abstract

In addition to its proven effectiveness in the treatment of recurrent Clostridium difficile infections (rCDI), fecal microbiota transplantation (FMT) is on the rise to become one of the most studied innovative therapies for the treatment of several complex diseases. This review aims to discuss the many promising applications of FMT in intestinal diseases such as inflammatory bowel diseases (IBD) and extraintestinal diseases such as neuropsychiatric disorders, metabolic syndrome, and autoimmune diseases. For each disease group, preclinical data will be presented in addition to clinical trial evidence.