Nature Communications (Oct 2019)
Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance
- Réka Spohn,
- Lejla Daruka,
- Viktória Lázár,
- Ana Martins,
- Fanni Vidovics,
- Gábor Grézal,
- Orsolya Méhi,
- Bálint Kintses,
- Mónika Számel,
- Pramod K. Jangir,
- Bálint Csörgő,
- Ádám Györkei,
- Zoltán Bódi,
- Anikó Faragó,
- László Bodai,
- Imre Földesi,
- Diána Kata,
- Gergely Maróti,
- Bernadett Pap,
- Roland Wirth,
- Balázs Papp,
- Csaba Pál
Affiliations
- Réka Spohn
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- Lejla Daruka
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- Viktória Lázár
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- Ana Martins
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- Fanni Vidovics
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- Gábor Grézal
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- Orsolya Méhi
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- Bálint Kintses
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- Mónika Számel
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- Pramod K. Jangir
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- Bálint Csörgő
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- Ádám Györkei
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- Zoltán Bódi
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- Anikó Faragó
- Doctoral School of Biology, Faculty of Science and Informatics, University of Szeged
- László Bodai
- Department of Biochemistry and Molecular Biology, University of Szeged
- Imre Földesi
- Department of Laboratory Medicine, University of Szeged
- Diána Kata
- Department of Laboratory Medicine, University of Szeged
- Gergely Maróti
- Institute of Plant Biology, Biological Research Centre, Hungarian Academy of Sciences
- Bernadett Pap
- Institute of Plant Biology, Biological Research Centre, Hungarian Academy of Sciences
- Roland Wirth
- Department of Biotechnology, University of Szeged
- Balázs Papp
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- Csaba Pál
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- DOI
- https://doi.org/10.1038/s41467-019-12364-6
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Antimicrobial peptides (AMPs) are emerging as drug candidates, but the risk of pathogen resistance is not well understood. Here, the authors investigate AMP resistance evolution in E. coli, finding physicochemical features that make AMPs less prone to resistance and no cross- or horizontally-acquired resistance.
