International Journal of COPD (Mar 2023)
Plasma miR-150-5p as a Biomarker for Chronic Obstructive Pulmonary Disease
Abstract
Yichuan Ding,1– 3,* Sihui Tang,1,2,4,* Zihan Zhou,1– 3 Hui Wei,1– 3 Wanchun Yang1– 3 1Department of Respiratory and Critical Care Medicine, the Second People’s Hospital of Hefei, Hefei, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, Hefei Hospital Affiliated to Anhui Medical University, Hefei, People’s Republic of China; 3The Fifth Clinical College of Anhui Medical University, Hefei, People’s Republic of China; 4Department of Respiratory and Critical Care Medicine, the Second People’s Hospital of Hefei Affiliated to Bengbu Medical University, Bengbu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wanchun Yang, Department of Respiratory and Critical Care Medicine, the Second People’s Hospital of Hefei, Hefei, Anhui, 230011, People’s Republic of China, Tel +8662965684, Fax +8662965684, Email [email protected]: To investigate the potential of plasma microRNA-150-5p (miR-150-5p) as a biomarker for chronic obstructive pulmonary disease (COPD) and its relationship with clinical indicators such as pulmonary function.Patients and Methods: Fifty-nine patients with COPD and twenty-six healthy control individuals were recruited in the Second People’s Hospital of Hefei from September 2021 to September 2022. The plasma expression level of miR-150-5p was measured by quantitative real-time polymerase chain reaction.Results: The miR-150-5p level in the COPD group was significantly lower than that in the control group, and the relative expression was lower in patients with severe airflow limitation than those with mild limitation. Plasma miR-150-5p levels were positively correlated with pulmonary function indicators and negatively correlated with the white blood cell count and C-reactive protein level. The receiver operating characteristic curve suggested that plasma miR-150-5p had predictive value for COPD (area under curve = 0.819, sensitivity 64.4%, specificity 92.3%).Conclusion: MiR-150-5p can be useful for the diagnosis and disease assessment of COPD, and has value as a biomarker for COPD.Keywords: chronic obstructive pulmonary disease, miR-150-5p, biomarker, miRNA
