Nature Communications (Sep 2020)
SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells
- Elisabeth Anne Adanma Obara,
- Diana Aguilar-Morante,
- Rikke Darling Rasmussen,
- Alex Frias,
- Kristoffer Vitting-Serup,
- Yi Chieh Lim,
- Kirstine Juul Elbæk,
- Henriette Pedersen,
- Lina Vardouli,
- Kamilla Ellermann Jensen,
- Jane Skjoth-Rasmussen,
- Jannick Brennum,
- Lucie Tuckova,
- Robert Strauss,
- Christoffel Dinant,
- Jiri Bartek,
- Petra Hamerlik
Affiliations
- Elisabeth Anne Adanma Obara
- Brain Tumor Biology, Danish Cancer Society Research Center
- Diana Aguilar-Morante
- Brain Tumor Biology, Danish Cancer Society Research Center
- Rikke Darling Rasmussen
- Brain Tumor Biology, Danish Cancer Society Research Center
- Alex Frias
- Brain Tumor Biology, Danish Cancer Society Research Center
- Kristoffer Vitting-Serup
- Brain Tumor Biology, Danish Cancer Society Research Center
- Yi Chieh Lim
- Brain Tumor Biology, Danish Cancer Society Research Center
- Kirstine Juul Elbæk
- Brain Tumor Biology, Danish Cancer Society Research Center
- Henriette Pedersen
- Brain Tumor Biology, Danish Cancer Society Research Center
- Lina Vardouli
- Brain Tumor Biology, Danish Cancer Society Research Center
- Kamilla Ellermann Jensen
- Brain Tumor Biology, Danish Cancer Society Research Center
- Jane Skjoth-Rasmussen
- Department of Neurosurgery, Copenhagen University Hospital
- Jannick Brennum
- Department of Neurosurgery, Copenhagen University Hospital
- Lucie Tuckova
- Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University
- Robert Strauss
- Genome Integrity Unit, Danish Cancer Society Research Center
- Christoffel Dinant
- Genome Integrity Unit, Danish Cancer Society Research Center
- Jiri Bartek
- Genome Integrity Unit, Danish Cancer Society Research Center
- Petra Hamerlik
- Brain Tumor Biology, Danish Cancer Society Research Center
- DOI
- https://doi.org/10.1038/s41467-020-18549-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Cancer stem cells can evade treatment. Here, the authors perform an in vitro screen to identify proteins that are involved in protecting glioma cancer stem cells from therapy and find that SPT6 increases BRCA1 expression and drives error-free DNA repair, thereby ensuring the survival of the cells.
