TMEM16K is an interorganelle regulator of endosomal sorting

Maja Petkovic; Juan Oses-Prieto; Alma Burlingame; Lily Yeh Jan; Yuh Nung Jan

doi:10.1038/s41467-020-17016-8

Nature Communications (Jul 2020)

TMEM16K is an interorganelle regulator of endosomal sorting

Maja Petkovic,
Juan Oses-Prieto,
Alma Burlingame,
Lily Yeh Jan,
Yuh Nung Jan

Affiliations

Maja Petkovic: Departments of Physiology, Biochemistry and Biophysics, University of California at San Francisco
Juan Oses-Prieto: Department of Pharmaceutical Chemistry, University of California San Francisco
Alma Burlingame: Department of Pharmaceutical Chemistry, University of California San Francisco
Lily Yeh Jan: Departments of Physiology, Biochemistry and Biophysics, University of California at San Francisco
Yuh Nung Jan: Departments of Physiology, Biochemistry and Biophysics, University of California at San Francisco

DOI: https://doi.org/10.1038/s41467-020-17016-8
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

Read online

The endolysosomal pathway plays an important role in regulating protein and lipid sorting and degradation. Here, the authors show that TMEM16K, an endoplasmic reticulum lipid scramblase, forms ER-endosome contact sites where it regulates endosomal sorting.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal