Numerical simulation of the fluid dynamics within the tissue engineering scaffolds micro-tubes

Abstract

The core of tissue engineering is the fabrication of a complex three-dimensional space with cells and biomaterials. In the development of porous scaffolds in vitro, no matter the seed cells ran into the scaffold, or its excretion of waste discharged scaffolds, they both need the nutrient solution to be brought into or taken out. Therefore, the flow of the nutrient solution, cells and metabolic waste for the profitable living in vitro culture plays a significant role. the paper constructed bone scaffold models of different geometric parameters, analog cells, and nutrient solution flow conditions in the scaffolds using the FLUENT software. By making a contrastive analysis with the simulated result, the internal organizational design parameters of scaffold for tissue engineering is optimized and a certain amount of data and a theoretical basis for the internal bone scaffold structure design is provided.

Keywords

• Tissue engineering
• Scaffold models
• Operating parameters
• Velocity distribution