Cancer Management and Research (Apr 2022)
Association of Hypertension and Breast Cancer: Antihypertensive Drugs as an Effective Adjunctive in Breast Cancer Therapy
Abstract
Yuanyuan Fan,1,* Nazeer Hussain Khan,1,* Muhammad Farhan Ali Khan,2 MD Faysal Ahammad,3 Tayyaba Zulfiqar,2 Razia Virk,4 Enshe Jiang5 1School of Life Sciences, Henan University, Kaifeng, Henan, 475004, People’s Republic of China; 2Department of Pharmacy, Quaid I Azam University, Islamabad, Pakistan; 3Key Laboratory of Natural Medicine and Immune Engineering, School of Medicine, Henan University, Kaifeng, People’s Republic of China; 4Department of Bio-Sciences, University Wah, Rawalpindi, Pakistan; 5Institute of Nursing and Health, Henan University, Kaifeng, 475004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Enshe Jiang, Email [email protected]: Breast cancer (BC) is the most common malignancy affecting women, and its incidence in younger women is rising worldwide. Early-onset of BC is a multi-step process involving various biological aggressive tumors such as triple negative and human epidermal growth factor 2 (HER2)-positive cancers. BC prevention is still arduous across the globe. A series of observational studies have established a conclusive non-genetic clinical link between hypertension (HTN) and the development of invasive BC. Those clinical associations have driven a pharmacological seek to use the anti-hypertension (AHTN) drugs as an effective adjunctive in BC therapy. The use of AHTN, especially beta-blockers and thiazides, has been recognized as a potent anti-tumor drug to mitigate BC progression, reduce the side effects of cancer treatment, and stop the reoccurrence of cancer in the survivors. Considering the dire need to disseminate the research on how AHTN drugs can be opted as the effective adjunctive therapy to cure the BC, the current review aimed to provide an update on novel understandings on association and mechanisms of AHTN-drugs against BC as an additional cancer therapy.Keywords: breast cancer, beta blockers, hypertension, hypertensive drugs, thiazides
