Antiviral therapy of chronic hepatitis C: 30 years success story

Abstract

Exactly 30 years ago, hepatitis C virus was identified. Over the years, tremendous success has been achieved in the treatment of hepatitis C, which is currently considered to be an almost completely curable disease. The review presents the main stages in the development of hepatitis C antiviral therapy, the efficacy of various treatment regimens. The greatest progress in treatment was noted over the past 5 years when drugs with direct antiviral action appeared and began to be widely used, including in Russia, which ensure the elimination of the virus in 90-95% of cases.

Keywords

• hcv
• antiviral therapy
• interferon alfa
• ribavirin
• protease inhibitors
• polymerase inhibitors