Spinal cord injury as a trigger for changes in the intestinal microbiota

Abstract

Objective. To analyze the peculiarities of changes in intestinal microbiota in spinal cord injury. Material and Methods. The literature search was carried out for the period of 2012–2022 in the PubMed, ScienceDirect, eLibrary and GoogleScholar databases for the following keywords: spinal cord injury, microbiota, and dysbacteriosis. Out of 220 literature sources, 40 full-text articles were selected which analyze the influence of spinal cord injury on the state of the intestinal microbiota using an innovative method of metagenomic high-throughput 16S sequencing. Results. Literature data on the pathogenesis of organ dysfunction in spinal cord injury, as well as its impact on the state of the intestinal microbiota are presented. The results of experimental and clinical studies of the intestinal microbiota in spinal cord injury and its influence on the development and course of the pathological condition are reported. Conclusion. Understanding how the intestinal microbiota changes after spinal cord injury and what role it plays in potentiating inflammation or protecting the spinal cord from secondary injury and infections is very important in determining the strategy and tactics for managing patients. Possession of methods for correcting intestinal microbiota disorders in SCI is important in the treatment of such patients.

Keywords

• spinal cord injury
• microbiota
• dysbacteriosis