Nature Communications (Dec 2021)

Hydroxylamine-mediated C–C amination via an aza-hock rearrangement

  • Tao Wang,
  • Philipp M. Stein,
  • Hongwei Shi,
  • Chao Hu,
  • Matthias Rudolph,
  • A. Stephen K. Hashmi

DOI
https://doi.org/10.1038/s41467-021-27271-y
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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Syntheses of anilines occur through a variety of methods, most requiring transition metals or multiple steps. Here the authors disclose a protocol to form anilines from benzyl alcohols via an aza-Hock rearrangement that uses only a sulfonyl hydroxylamine and solvent.