Nature Communications (Jan 2018)
Lack of beta-arrestin signaling in the absence of active G proteins
- Manuel Grundmann,
- Nicole Merten,
- Davide Malfacini,
- Asuka Inoue,
- Philip Preis,
- Katharina Simon,
- Nelly Rüttiger,
- Nicole Ziegler,
- Tobias Benkel,
- Nina Katharina Schmitt,
- Satoru Ishida,
- Ines Müller,
- Raphael Reher,
- Kouki Kawakami,
- Ayumi Inoue,
- Ulrike Rick,
- Toni Kühl,
- Diana Imhof,
- Junken Aoki,
- Gabriele M. König,
- Carsten Hoffmann,
- Jesus Gomeza,
- Jürgen Wess,
- Evi Kostenis
Affiliations
- Manuel Grundmann
- Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn
- Nicole Merten
- Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn
- Davide Malfacini
- Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn
- Asuka Inoue
- Graduate School of Pharmaceutical Science, Tohoku University
- Philip Preis
- Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn
- Katharina Simon
- Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn
- Nelly Rüttiger
- Institute for Molecular Cell Biology, CMB-Center for Molecular Biomedicine, University Hospital Jena
- Nicole Ziegler
- Bio-Imaging-Center/Rudolf-Virchow-Center, Institute of Pharmacology, University of Wuerzburg
- Tobias Benkel
- Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn
- Nina Katharina Schmitt
- Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn
- Satoru Ishida
- Graduate School of Pharmaceutical Science, Tohoku University
- Ines Müller
- Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn
- Raphael Reher
- Institute for Pharmaceutical Biology, University of Bonn
- Kouki Kawakami
- Graduate School of Pharmaceutical Science, Tohoku University
- Ayumi Inoue
- Graduate School of Pharmaceutical Science, Tohoku University
- Ulrike Rick
- Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn
- Toni Kühl
- Pharmaceutical Biochemistry and Bioanalytics, Institute of Pharmacy, University of Bonn
- Diana Imhof
- Pharmaceutical Biochemistry and Bioanalytics, Institute of Pharmacy, University of Bonn
- Junken Aoki
- Graduate School of Pharmaceutical Science, Tohoku University
- Gabriele M. König
- Institute for Pharmaceutical Biology, University of Bonn
- Carsten Hoffmann
- Institute for Molecular Cell Biology, CMB-Center for Molecular Biomedicine, University Hospital Jena
- Jesus Gomeza
- Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn
- Jürgen Wess
- Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Evi Kostenis
- Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn
- DOI
- https://doi.org/10.1038/s41467-017-02661-3
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
Arrestins terminate signaling from GPCRs, but several lines of evidence suggest that they are also able to transduce signals independently of G proteins. Here, the authors systematically ablate G proteins in cell lines, and show that arrestins are unable to act as genuine signal initiators.
