Probing Affinity, Avidity, Anticooperativity, and Competition in Antibody and Receptor Binding to the SARS-CoV‑2 Spike by Single Particle Mass Analyses

• Victor Yin,
• Szu-Hsueh Lai,
• Tom G. Caniels,
• Philip J. M. Brouwer,
• Mitch Brinkkemper,
• Yoann Aldon,
• Hejun Liu,
• Meng Yuan,
• Ian A. Wilson,
• Rogier W. Sanders,
• Marit J. van Gils,
• Albert J. R. Heck

Affiliations

Victor Yin

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

Szu-Hsueh Lai

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

Tom G. Caniels

Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam, The Netherlands

Philip J. M. Brouwer

Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam, The Netherlands

Mitch Brinkkemper

Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam, The Netherlands

Yoann Aldon

Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam, The Netherlands

Hejun Liu

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States

Meng Yuan

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States

Ian A. Wilson

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States

Rogier W. Sanders

Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam, The Netherlands

Marit J. van Gils

Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam, The Netherlands

Albert J. R. Heck

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands