European Journal of Case Reports in Internal Medicine (Feb 2023)

Malignant Syphilis: A Rare Case of Early Secondary Syphilis in an Immunocompetent Patient

  • Ramiro Sá Lopes,
  • Ana Sara Monteiro,
  • Rosário Saez,
  • Carlos Candeias,
  • Catarina Mendonça

DOI
https://doi.org/10.12890/2023_003712

Abstract

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Early malignant syphilis is an uncommon form of secondary syphilis and characterized by pleomorphic multiple round-to-oval papules, some with necrosis, and associated with systemic signs and symptoms. Usually seen in immunosuppressed patients, mainly those infected with HIV, it can also be observed in immunocompetent patients. We report a case in a young healthy woman with the characteristic features of the disease and with favourable skin lesion evolution after appropriate treatment with penicillin.

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