Intravenous infusion of prostaglandin E1 therapy in extremity ischemia

Abstract

Prostaglandins are potent vasoactive agents with wide variety of other actions - vasodilatation, fibrinolysis and inhibition of platelet aggregation. PGE1 was the agent used since 1973 for cardiovascular diseases, mainly in patients with advanced PVD. PGE1 intra venous infusion has shown to be beneficial in limb threatening ischemia, especially when reconstructive procedures are not feasible and also as an adjunct when there is residual ischemia after revascularization. The review of literature and the use of PGE1 in CLI is presented here along with our experience in NIMS.

Keywords

• Extremity ischemia
• prostaglandin E1 therapy
• prostaglandin infusion