Thymidine Phosphorylase Promotes Abdominal Aortic Aneurysm via VSMC Modulation and Matrix Remodeling in Mice and Humans

Liang Hong; Hong Yue; Dunpeng Cai; Autumn DeHart; Gretel Toloza-Alvarez; Lili Du; Xianwu Zhou; Xiaoping Fan; Huanlei Huang; Shiyou Chen; Shaik O. Rahaman; Jian Zhuang; Wei Li

doi:10.1155/cdr/1129181

Cardiovascular Therapeutics (Jan 2024)

Thymidine Phosphorylase Promotes Abdominal Aortic Aneurysm via VSMC Modulation and Matrix Remodeling in Mice and Humans

Liang Hong,
Hong Yue,
Dunpeng Cai,
Autumn DeHart,
Gretel Toloza-Alvarez,
Lili Du,
Xianwu Zhou,
Xiaoping Fan,
Huanlei Huang,
Shiyou Chen,
Shaik O. Rahaman,
Jian Zhuang,
Wei Li

Affiliations

Liang Hong: Department of Cardiac Surgery
Hong Yue: Department of Biomedical Sciences
Dunpeng Cai: Department of Surgery
Autumn DeHart: Department of Biomedical Sciences
Gretel Toloza-Alvarez: Department of Biomedical Sciences
Lili Du: Department of Biomedical Sciences
Xianwu Zhou: Department of Cardiac Surgery
Xiaoping Fan: Department of Cardiovascular Surgery
Huanlei Huang: Department of Cardiovascular Surgery
Shiyou Chen: Department of Surgery
Shaik O. Rahaman: Department of Nutrition and Food Science
Jian Zhuang: Department of Cardiac Surgery
Wei Li: Department of Biomedical Sciences

DOI: https://doi.org/10.1155/cdr/1129181
Journal volume & issue: Vol. 2024

Abstract

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Conclusion: TYMP emerges as a novel regulatory force in vascular biology, influencing VSMC function and inflammatory responses to promote AAA development.

Published in Cardiovascular Therapeutics

ISSN: 1755-5914 (Print); 1755-5922 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Therapeutics. Pharmacology; Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://onlinelibrary.wiley.com/journal/4702

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