International Journal of General Medicine (May 2023)
Correlation of Great Chinese Famine Exposure During Early Life to Prevalence of Kidney Stone in Adulthood
Abstract
Yu-Qin Yan,1 Yu-Qing Huang,2 Ying-Qing Feng2 1Department of Cardiology, People’s Hospital of Shenzhen Baoan District, Shenzhen, People’s Republic of China; 2Department of Cardiology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People’s Republic of ChinaCorrespondence: Yu-Qin Yan, Department of Cardiology, People’s Hospital of Shenzhen Baoan District, No. 118, Longjing Second Road, Xinan Street, Baoan District, Shenzhen, 518100, People’s Republic of China, Tel/Fax +86-755-27788311, Email [email protected]: The Great Chinese Famine, as the famine of 1959– 1961 was often known. Famine exposure during early life was proven to be associated with some kidney diseases but has not been studied with kidney stone. We aimed to investigate the relationship between exposure to the Great Chinese Famine in early life and the incidence of kidney stone in adulthood.Methods: From 1 January 2017 to 31 December 2018, a total of 19,658 eligible adults were recruited in a cross-sectional survey who were born between 1 October 1952 and 30 September 1964 in Guangdong, China. Participants were separated into kidney stone and none-kidney stone groups based on kidney stone status. According to birth data, participants were divided into non-exposed, fetal-exposed, early-, mid-, and late-childhood-exposed groups. Multivariate logistic regression, subgroup analysis and interaction test were used to estimate the odds ratios (ORs) and confidence intervals (CIs) between famine exposure and kidney stone.Results: In total, 19,658 (12,246 female, mean age 59.31 ± 3.68 years) subjects were enrolled, and 3219 (16.38%) participants with kidney stone. The prevalence of kidney in none-, fetal-, early-, mid-, and late-childhood-exposed groups were 645 (14.9%), 437 (15.9%), 676 (16.3%), 743 (17.0%), and 718 (17.6%), respectively (P 0.05).Conclusion: This study found that exposure to the Great Chinese Famine during early life was independently associated with the increased incidence of kidney stone in adulthood.Keywords: Great Chinese Famine, early life, famine exposure, adulthood, kidney stone
