Activity of Adipokines and Inflammation in Development of Esophagitis in Overweight Patients with Gastroesophageal Reflux Disease

Abstract

The aim of the study — to examine the role of adipokines (leptin, adiponectin) and markers of inflammation in the development of gastroesophageal reflux disease (GERD) in obesity. The study included 92 patients, of them 48 patients with GERD and 44 — with obesity. Leptin concentration was significantly higher in obese patients compared to patients with GERD. Increase in BMI of patients with GERD provokes esophagitis of higher grades. Changes in the mucous membrane of the esophagus in patients with GERD following obesity are associated with increased levels of C-reactive protein in the blood serum. Severe erosive form of reflux disease in overweight patients is characterized by more significant changes of from adipocyte hormones and C-reactive protein.