Inhibition of amyloid beta toxicity in zebrafish with a chaperone-gold nanoparticle dual strategy

Ibrahim Javed; Guotao Peng; Yanting Xing; Tianyu Yu; Mei Zhao; Aleksandr Kakinen; Ava Faridi; Clare L. Parish; Feng Ding; Thomas P. Davis; Pu Chun Ke; Sijie Lin

doi:10.1038/s41467-019-11762-0

Nature Communications (Aug 2019)

Inhibition of amyloid beta toxicity in zebrafish with a chaperone-gold nanoparticle dual strategy

Ibrahim Javed,
Guotao Peng,
Yanting Xing,
Tianyu Yu,
Mei Zhao,
Aleksandr Kakinen,
Ava Faridi,
Clare L. Parish,
Feng Ding,
Thomas P. Davis,
Pu Chun Ke,
Sijie Lin

Affiliations

Ibrahim Javed: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University
Guotao Peng: College of Environmental Science and Engineering, Biomedical Multidisciplinary Innovation Research Institute, Shanghai East Hospital, Shanghai Institute of Pollution Control and Ecological Security, Key Laboratory of Yangtze River Water Environment, Tongji University
Yanting Xing: Department of Physics and Astronomy, Clemson University
Tianyu Yu: College of Environmental Science and Engineering, Biomedical Multidisciplinary Innovation Research Institute, Shanghai East Hospital, Shanghai Institute of Pollution Control and Ecological Security, Key Laboratory of Yangtze River Water Environment, Tongji University
Mei Zhao: College of Environmental Science and Engineering, Biomedical Multidisciplinary Innovation Research Institute, Shanghai East Hospital, Shanghai Institute of Pollution Control and Ecological Security, Key Laboratory of Yangtze River Water Environment, Tongji University
Aleksandr Kakinen: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University
Ava Faridi: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University
Clare L. Parish: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne
Feng Ding: Department of Physics and Astronomy, Clemson University
Thomas P. Davis: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University
Pu Chun Ke: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University
Sijie Lin: College of Environmental Science and Engineering, Biomedical Multidisciplinary Innovation Research Institute, Shanghai East Hospital, Shanghai Institute of Pollution Control and Ecological Security, Key Laboratory of Yangtze River Water Environment, Tongji University

DOI: https://doi.org/10.1038/s41467-019-11762-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Treating Alzheimer’s disease, one of the most common neurodegenerative diseases, is of wide interest. Here, the authors report on the development of casein coated gold nanoparticles which were able to cross the blood brain barrier and protect against amyloid beta toxicity in a zebrafish model.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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