Nature Communications (Jun 2021)
Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission
- Xiao L. Chang,
- Gabriela M. Webb,
- Helen L. Wu,
- Justin M. Greene,
- Shaheed Abdulhaqq,
- Katherine B. Bateman,
- Jason S. Reed,
- Cleiton Pessoa,
- Whitney C. Weber,
- Nicholas Maier,
- Glen M. Chew,
- Roxanne M. Gilbride,
- Lina Gao,
- Rebecca Agnor,
- Travis Giobbi,
- Jeffrey Torgerson,
- Don Siess,
- Nicole Burnett,
- Miranda Fischer,
- Oriene Shiel,
- Cassandra Moats,
- Bruce Patterson,
- Kush Dhody,
- Scott Kelly,
- Nader Pourhassan,
- Diogo M. Magnani,
- Jeremy Smedley,
- Benjamin N. Bimber,
- Nancy L. Haigwood,
- Scott G. Hansen,
- Timothy R. Brown,
- Lishomwa C. Ndhlovu,
- Jonah B. Sacha
Affiliations
- Xiao L. Chang
- Vaccine & Gene Therapy Institute
- Gabriela M. Webb
- Vaccine & Gene Therapy Institute
- Helen L. Wu
- Vaccine & Gene Therapy Institute
- Justin M. Greene
- Vaccine & Gene Therapy Institute
- Shaheed Abdulhaqq
- Vaccine & Gene Therapy Institute
- Katherine B. Bateman
- Vaccine & Gene Therapy Institute
- Jason S. Reed
- Vaccine & Gene Therapy Institute
- Cleiton Pessoa
- Vaccine & Gene Therapy Institute
- Whitney C. Weber
- Vaccine & Gene Therapy Institute
- Nicholas Maier
- Vaccine & Gene Therapy Institute
- Glen M. Chew
- University of Hawaii
- Roxanne M. Gilbride
- Vaccine & Gene Therapy Institute
- Lina Gao
- Oregon National Primate Research Center, Oregon Health & Science University
- Rebecca Agnor
- Oregon National Primate Research Center, Oregon Health & Science University
- Travis Giobbi
- Oregon National Primate Research Center, Oregon Health & Science University
- Jeffrey Torgerson
- Oregon National Primate Research Center, Oregon Health & Science University
- Don Siess
- Oregon National Primate Research Center, Oregon Health & Science University
- Nicole Burnett
- Oregon National Primate Research Center, Oregon Health & Science University
- Miranda Fischer
- Oregon National Primate Research Center, Oregon Health & Science University
- Oriene Shiel
- Oregon National Primate Research Center, Oregon Health & Science University
- Cassandra Moats
- Oregon National Primate Research Center, Oregon Health & Science University
- Bruce Patterson
- IncellDX
- Kush Dhody
- Amarex Clinical Research LLC
- Scott Kelly
- CytoDyn Inc.
- Nader Pourhassan
- CytoDyn Inc.
- Diogo M. Magnani
- MassBiologics of the University of Massachusetts Medical School
- Jeremy Smedley
- Oregon National Primate Research Center, Oregon Health & Science University
- Benjamin N. Bimber
- Vaccine & Gene Therapy Institute
- Nancy L. Haigwood
- Vaccine & Gene Therapy Institute
- Scott G. Hansen
- Vaccine & Gene Therapy Institute
- Timothy R. Brown
- Palm Springs
- Lishomwa C. Ndhlovu
- Department of Medicine, Division of Infectious Disease, Weill Cornell Medicine
- Jonah B. Sacha
- Vaccine & Gene Therapy Institute
- DOI
- https://doi.org/10.1038/s41467-021-23697-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
CCR5 is a co-receptor for many transmitted HIV strains. Here, the authors show that biweekly injection of the CCR5-specific antibody Leronlimab protects rhesus macaques against infection following repeated intrarectal challenges of a CCR5-tropic SHIV.
