Nature Communications (Dec 2019)
Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action
- Bálint Kintses,
- Pramod K. Jangir,
- Gergely Fekete,
- Mónika Számel,
- Orsolya Méhi,
- Réka Spohn,
- Lejla Daruka,
- Ana Martins,
- Ali Hosseinnia,
- Alla Gagarinova,
- Sunyoung Kim,
- Sadhna Phanse,
- Bálint Csörgő,
- Ádám Györkei,
- Eszter Ari,
- Viktória Lázár,
- István Nagy,
- Mohan Babu,
- Csaba Pál,
- Balázs Papp
Affiliations
- Bálint Kintses
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- Pramod K. Jangir
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- Gergely Fekete
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- Mónika Számel
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- Orsolya Méhi
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- Réka Spohn
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- Lejla Daruka
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- Ana Martins
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- Ali Hosseinnia
- Department of Biochemistry, University of Regina
- Alla Gagarinova
- Department of Biochemistry, University of Saskatchewan
- Sunyoung Kim
- Department of Biochemistry, University of Regina
- Sadhna Phanse
- Department of Biochemistry, University of Regina
- Bálint Csörgő
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- Ádám Györkei
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- Eszter Ari
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- Viktória Lázár
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- István Nagy
- Sequencing Platform, Institute of Biochemistry, Biological Research Centre
- Mohan Babu
- Department of Biochemistry, University of Regina
- Csaba Pál
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- Balázs Papp
- Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre
- DOI
- https://doi.org/10.1038/s41467-019-13618-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
The genetics underlying bacterial susceptibility to antimicrobial peptides (AMPs) remain unclear. Here, using a genome-wide chemical-genetic approach, the authors map the diversity of resistance determinants across AMPs in Escherichia coli and provide evidence that cross-resistance is prevalent only between AMPs with similar modes of action.
