Molecules
(Oct 2023)
Investigation of NO Role in Neural Tissue in Brain and Spinal Cord Injury
Viacheslav V. Andrianov,
Vladimir A. Kulchitsky,
Guzel G. Yafarova,
Leah V. Bazan,
Tatiana K. Bogodvid,
Irina B. Deryabina,
Lyudmila N. Muranova,
Dinara I. Silantyeva,
Almaz I. Arslanov,
Mikhail N. Paveliev,
Ekaterina V. Fedorova,
Tatiana A. Filipovich,
Aleksei V. Nagibov,
Khalil L. Gainutdinov
Affiliations
Viacheslav V. Andrianov
Zavoisky Physical-Technical Institute of the Russian Academy of Sciences, 420000 Kazan, Russia
Vladimir A. Kulchitsky
Brain Center, Institute of Physiology, National Academy of Sciences, 220012 Minsk, Belarus
Guzel G. Yafarova
Zavoisky Physical-Technical Institute of the Russian Academy of Sciences, 420000 Kazan, Russia
Leah V. Bazan
Zavoisky Physical-Technical Institute of the Russian Academy of Sciences, 420000 Kazan, Russia
Tatiana K. Bogodvid
Department of Human and Animals, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420000 Kazan, Russia
Irina B. Deryabina
Department of Human and Animals, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420000 Kazan, Russia
Lyudmila N. Muranova
Department of Human and Animals, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420000 Kazan, Russia
Dinara I. Silantyeva
Department of Human and Animals, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420000 Kazan, Russia
Almaz I. Arslanov
Department of Human and Animals, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420000 Kazan, Russia
Mikhail N. Paveliev
Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland
Ekaterina V. Fedorova
Brain Center, Institute of Physiology, National Academy of Sciences, 220012 Minsk, Belarus
Tatiana A. Filipovich
Brain Center, Institute of Physiology, National Academy of Sciences, 220012 Minsk, Belarus
Aleksei V. Nagibov
Brain Center, Institute of Physiology, National Academy of Sciences, 220012 Minsk, Belarus
Khalil L. Gainutdinov
Zavoisky Physical-Technical Institute of the Russian Academy of Sciences, 420000 Kazan, Russia
DOI
https://doi.org/10.3390/molecules28217359
Journal volume & issue
Vol. 28,
no. 21
Abstract
Read online
Nitric oxide (NO) production in injured and intact brain regions was compared by EPR spectroscopy in a model of brain and spinal cord injury in Wistar rats. The precentral gyrus of the brain was injured, followed by the spinal cord at the level of the first lumbar vertebra. Seven days after brain injury, a reduction in NO content of 84% in injured brain regions and 66% in intact brain regions was found. The difference in NO production in injured and uninjured brain regions persisted 7 days after injury. The copper content in the brain remained unchanged one week after modeling of brain and spinal cord injury. The data obtained in the experiments help to explain the problems in the therapy of patients with combined brain injury.
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