Eupatorin and Salviandulin-A, with Antimicrobial and Anti-Inflammatory Effects from <i>Salvia lavanduloides</i> Kunth Leaves
Manasés González-Cortazar,
David Osvaldo Salinas-Sánchez,
Maribel Herrera-Ruiz,
Dionisio Celerino Román-Ramos,
Alejandro Zamilpa,
Enrique Jiménez-Ferrer,
Ever A. Ble-González,
Patricia Álvarez-Fitz,
Ricardo Castrejón-Salgado,
Ma. Dolores Pérez-García
Affiliations
Manasés González-Cortazar
Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, Mexico
David Osvaldo Salinas-Sánchez
Centro de Investigación en Biodiversidad y Conservación (CIByC), Universidad Autónoma del Estado de Morelos (UAEM), Av. Universidad 1001, Col. Chamilpa, Cuernavaca 62209, Morelos, Mexico
Maribel Herrera-Ruiz
Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, Mexico
Dionisio Celerino Román-Ramos
Escuela de Estudios Superiores del Jicarero (EESJ), Universidad Autónoma del Estado de Morelos, Carretera Galeana-Tequesquitengo s/n Col. el Jicarero, Jojutla 62909, Morelos, Mexico
Alejandro Zamilpa
Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, Mexico
Enrique Jiménez-Ferrer
Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, Mexico
Ever A. Ble-González
División Académica de Ciencias Básicas, Universidad Juárez Autónoma de Tabasco, Carretera Cunduacán-Jalpa Km. 0.5, Cunduacán 86690, Tabasco, Mexico
Patricia Álvarez-Fitz
Laboratorio de Toxicologia, Cátedra CONACyT-Universidad Autónoma de Guerrero, Av. Lázaro Cárdenas s/n. Col. La Haciendita, Chilpancingo 39070, Guerrero, Mexico
Ricardo Castrejón-Salgado
Instituto Mexicano del Seguro Social, Unidad de Medicina Familiar Número 3, Avenida Insurgentes Esquina con Emiliano Zapata s/n., Centro, Jiutepec 62550, Morelos, Mexico
Ma. Dolores Pérez-García
Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, Mexico
This study describes the antimicrobial and anti-inflammatory effects from extracts obtained from the leaves of Salvia lavanduloides. The plant material was macerated with three solvents of ascending polarity (n-hexane (Sl-Hex), ethyl acetate (Sl-AcOEt), and dichloromethane (Sl-D)). The extracts, fractions (SlD-2 and SlD-3), and isolated compounds (15,16-epoxy-10-β-hydroxy-neo-cleroda-3,7,13(16),14-tetraene-17,12R:18,19-diolide (1), salviandulin A (2), and eupatorin (3)) were evaluated as antimicrobials against Gram-negative, Gram-positive bacteria and the fungus Candida albicans (Ca) using the minimum inhibitory concentration (MIC) and the anti-inflammatory activity induced by 13-acetate of 12-O-tetradecanoylforbol (TPA). Sl-D and Sl-AcOEt extracts, SlD-2 and SlD-3 fractions showed the highest antimicrobial activity. The isolated compounds showed good activity against Pseudomonas aeruginosa with a MIC 2) 70% and (3) 72%.
