Frontiers in Immunology (Sep 2022)
Determinants of anti-S immune response at 6 months after COVID-19 vaccination in a multicentric European cohort of healthcare workers – ORCHESTRA project
- Giulia Collatuzzo,
- Giovanni Visci,
- Francesco S. Violante,
- Stefano Porru,
- Gianluca Spiteri,
- Maria Grazia Lourdes Monaco,
- Francesca Larese Fillon,
- Corrado Negro,
- Christian Janke,
- Noemi Castelletti,
- Giuseppe De Palma,
- Emanuele Sansone,
- Dana Mates,
- Silvia Teodorescu,
- Eleonóra Fabiánová,
- Jana Bérešová,
- Luigi Vimercati,
- Silvio Tafuri,
- Mahsa Abedini,
- Giorgia Ditano,
- Shuffield S. Asafo,
- Paolo Boffetta,
- Paolo Boffetta,
- Orchestra WP5 Working Group,
- Carlotta Zunarelli,
- Roberta Bonfiglioli,
- Angela Carta,
- Giuseppe Verlato,
- Giuseppe Lippi,
- Davide Gibellini,
- Maria Diletta Pezzani,
- Lorena Torroni,
- Michael Hoelscher,
- Andreas Wieser,
- Christina Reinkemeyer,
- Michael Plank,
- Ivan Noreña,
- Raquel Rubio-Acero,
- Simon Winter,
- Mihaela Leustean,
- Ovidiu Perseca,
- Madalina Ipate,
- Agripina Rascu,
- Jozef Strhársky,
- Petra Hellebrandt,
- Daniela Križanová,
- Marianna Mrázová,
- Luigi De Maria,
- Stefania Sponselli,
- Pasquale Stefanizzi,
- Antonio Caputi
Affiliations
- Giulia Collatuzzo
- Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
- Giovanni Visci
- Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
- Francesco S. Violante
- Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
- Stefano Porru
- Section of Occupational Medicine, Department of Diagnostics and Public Health, University of Verona, Verona, Italy
- Gianluca Spiteri
- Clinical Unit of Occupational Medicine, University Hospital of Verona, Verona, Italy
- Maria Grazia Lourdes Monaco
- Clinical Unit of Occupational Medicine, University Hospital of Verona, Verona, Italy
- Francesca Larese Fillon
- Unit of Occupational Medicine, University of Trieste, Trieste, Italy
- Corrado Negro
- Unit of Occupational Medicine, University of Trieste, Trieste, Italy
- Christian Janke
- Division of Infectious Diseases and Tropical Medicine, Ludwig Maximilian University (LMU) Klinikum, Munich, Germany
- Noemi Castelletti
- Division of Infectious Diseases and Tropical Medicine, Ludwig Maximilian University (LMU) Klinikum, Munich, Germany
- Giuseppe De Palma
- Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy
- Emanuele Sansone
- Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy
- Dana Mates
- National Institute of Public Health, Bucharest, Romania
- Silvia Teodorescu
- National Institute of Public Health, Bucharest, Romania
- Eleonóra Fabiánová
- Occupational Health Department, Regional Authority of Public Health, Banská Bystrica, Slovakia
- Jana Bérešová
- Epidemiology Department, Regional Authority of Public Health, Banská Bystrica, Slovakia
- Luigi Vimercati
- 0Interdisciplinary Department of Medicine, University of Bari, Bari, Italy
- Silvio Tafuri
- 0Interdisciplinary Department of Medicine, University of Bari, Bari, Italy
- Mahsa Abedini
- Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
- Giorgia Ditano
- Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
- Shuffield S. Asafo
- Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
- Paolo Boffetta
- Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
- Paolo Boffetta
- 1Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, United States
- Orchestra WP5 Working Group
- Carlotta Zunarelli
- Roberta Bonfiglioli
- Angela Carta
- Giuseppe Verlato
- Giuseppe Lippi
- Davide Gibellini
- Maria Diletta Pezzani
- Lorena Torroni
- Michael Hoelscher
- Andreas Wieser
- Christina Reinkemeyer
- Michael Plank
- Ivan Noreña
- Raquel Rubio-Acero
- Simon Winter
- Mihaela Leustean
- Ovidiu Perseca
- Madalina Ipate
- Agripina Rascu
- Jozef Strhársky
- Petra Hellebrandt
- Daniela Križanová
- Marianna Mrázová
- Luigi De Maria
- Stefania Sponselli
- Pasquale Stefanizzi
- Antonio Caputi
- DOI
- https://doi.org/10.3389/fimmu.2022.986085
- Journal volume & issue
-
Vol. 13
Abstract
BackgroundThe duration of immune response to COVID-19 vaccination is of major interest. Our aim was to analyze the determinants of anti-SARS-CoV-2 IgG titer at 6 months after 2-dose vaccination in an international cohort of vaccinated healthcare workers (HCWs).MethodsWe analyzed data on levels of anti-SARS-CoV-2 Spike antibodies and sociodemographic and clinical characteristics of 6,327 vaccinated HCWs from 8 centers from Germany, Italy, Romania and Slovakia. Time between 1st dose and serology ranged 150-210 days. Serological levels were log-transformed to account for the skewness of the distribution and normalized by dividing them by center-specific standard errors, obtaining standardized values. We fitted center-specific multivariate regression models to estimate the cohort-specific relative risks (RR) of an increase of 1 standard deviation of log antibody level and corresponding 95% confidence interval (CI), and finally combined them in random-effects meta-analyses.ResultsA 6-month serological response was detected in 99.6% of HCWs. Female sex (RR 1.10, 95%CI 1.00-1.21), past infection (RR 2.26, 95%CI 1.73-2.95) and two vaccine doses (RR 1.50, 95%CI 1.22-1.84) predicted higher IgG titer, contrary to interval since last dose (RR for 10-day increase 0.94, 95%CI 0.91-0.97) and age (RR for 10-year increase 0.87, 95%CI 0.83-0.92). M-RNA-based vaccines (p<0.001) and heterologous vaccination (RR 2.46, 95%CI 1.87-3.24, one cohort) were associated with increased antibody levels.ConclusionsFemale gender, young age, past infection, two vaccine doses, and m-RNA and heterologous vaccination predicted higher antibody level at 6 months. These results corroborate previous findings and offer valuable data for comparison with trends observed with longer follow-ups.
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