Dapsone-induced pure red cell aplasia and cholestatic jaundice: A new experience for diagnosis and management

Abstract

Dapsone (4,4′- diaminodiphenylsulfone) is the parent compound of the sulfones, and it has potent antiparasitic, anti-inflammatory, and immunomodulatory effects. It is used in the treatment of leprosy, dermatitis herpetiformis, and prophylactically to prevent Pneumocystis pneumonia and toxoplasmosis in patients unable to tolerate trimethoprim with sulfamethoxazole. We hereby report a case of dapsone toxicity who developed pure red cell aplasia and cholestatic jaundice in a suspected case of dermatitis herpetiformis. Patient had an excellent response to corticosteroids after withdrawal of dapsone.

Keywords

• Cholestatic jaundice; Dapsone; dermatitis herpetiformis; pure red cell aplasia