Investigation of a UK biobank cohort reveals causal associations of self-reported walking pace with telomere length

Paddy C. Dempsey; Crispin Musicha; Alex V. Rowlands; Melanie Davies; Kamlesh Khunti; Cameron Razieh; Iain Timmins; Francesco Zaccardi; Veryan Codd; Christopher P. Nelson; Tom Yates; Nilesh J. Samani

doi:10.1038/s42003-022-03323-x

Communications Biology (Apr 2022)

Investigation of a UK biobank cohort reveals causal associations of self-reported walking pace with telomere length

Paddy C. Dempsey,
Crispin Musicha,
Alex V. Rowlands,
Melanie Davies,
Kamlesh Khunti,
Cameron Razieh,
Iain Timmins,
Francesco Zaccardi,
Veryan Codd,
Christopher P. Nelson,
Tom Yates,
Nilesh J. Samani

Affiliations

Paddy C. Dempsey: Diabetes Research Centre, University of Leicester, Leicester General Hospital
Crispin Musicha: NIHR Leicester Biomedical Research Centre, Leicester General and Glenfield Hospitals
Alex V. Rowlands: Diabetes Research Centre, University of Leicester, Leicester General Hospital
Melanie Davies: Diabetes Research Centre, University of Leicester, Leicester General Hospital
Kamlesh Khunti: NIHR Collaboration for Leadership in Applied Health Research and Care—East Midlands, University as Leicester
Cameron Razieh: Diabetes Research Centre, University of Leicester, Leicester General Hospital
Iain Timmins: Leicester Diabetes Centre, Leicester General Hospital, University Hospitals of Leicester NHS Trust
Francesco Zaccardi: NIHR Collaboration for Leadership in Applied Health Research and Care—East Midlands, University as Leicester
Veryan Codd: NIHR Leicester Biomedical Research Centre, Leicester General and Glenfield Hospitals
Christopher P. Nelson: NIHR Leicester Biomedical Research Centre, Leicester General and Glenfield Hospitals
Tom Yates: Diabetes Research Centre, University of Leicester, Leicester General Hospital
Nilesh J. Samani: NIHR Leicester Biomedical Research Centre, Leicester General and Glenfield Hospitals

DOI: https://doi.org/10.1038/s42003-022-03323-x
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 7

Abstract

Read online

Mendelian randomisation analysis of the UK Biobank cohort, supported by analyses of accelerometer-measured activity intensity, reveals that genetically-determined walking pace is associated with longer leucocyte telomere length (LTL), hinting at how brisk walking could offer health benefits.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal