A Short Review on Cardiotonic Steroids and Their Aminoguanidine Analogues

Abstract

A short review on cardiotonic steroids and their analogues is presented. The natural, semisynthetic and synthetic derivatives, as well as their mechanism of action and structure-activity relationships are shown, with a special reference to aminoguanidine derivatives.

Keywords

• Digitalis glycosides analogues
• structure-activity relationships
• inotropic activity
• Na+
• K+-ATPase
• aminoguanidine analogues