Asymmetric Synthesis of 1,2-Limonene Epoxides by Jacobsen Epoxidation

Abstract

Abstract This study reported an asymmetric synthesis of 1,2-limonene epoxides. The absolute stereochemistry was controlled by a Jacobsen epoxidation of cis-1,2-limonene epoxide (with diastereomeric excess of 98%) and trans-1,2-limonene epoxide (with diastereomeric excess of 94%), which could be used as important raw materials for the preparation of related cannabinoid drugs.

Keywords

• jacobsen epoxidation
• 1,2 limonene epoxides
• asymmetric synthesis