Sexual Differences in Delayed Postresuscitative Brain Changes (Experimental Study)

Abstract

Objective: to examine gender-related differences in the postresuscitative brain functional and structural changes.Materials and methods. Congenital and acquired behaviors were studied in 100 adult albino rats of both sexes in the control and after experienced 12-min cardiac arrest during 3 months (6 tests); the conditions of highly sensitive to ischemia of cerebral formations were subject to neuromorphological quantitative studies, and biochemical plasma parameters were determined.Results. Sexual differences in the integrative activity of the brain, in the state of neuronal populations in different regions of the hippocampus and cerebellum, and in plasma biochemical parameters were established in normalcy. Common and gender-related functional and structural changes of the brain and changes in plasma biochemical parameters were revealed in the postresuscitative period.Conclusion. Further studies of the gender-related mechanisms of development are required to develop specific methods for the prevention and therapy for disease.

Keywords

• clinical death
• emotional reactivity
• orientative-exploratory reaction
• learning
• neuronal populations
• morphometric analysis
• blood biochemistry