A plant Bro1 domain protein BRAF regulates multivesicular body biogenesis and membrane protein homeostasis

Abstract

The ESCRT complex contributes to selective vacuolar degradation of membrane proteins. Here, the authors show that the plant-specific BRAF protein negatively regulates intraluminal vesicle formation and membrane protein degradation by preventing FREE1 binding to the ESCRT-I complex protein Vps23.