Nature Communications (Sep 2019)

Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation

  • Antonella Managò,
  • Valentina Audrito,
  • Francesca Mazzola,
  • Leonardo Sorci,
  • Federica Gaudino,
  • Katiuscia Gizzi,
  • Nicoletta Vitale,
  • Danny Incarnato,
  • Gabriele Minazzato,
  • Alice Ianniello,
  • Antonio Varriale,
  • Sabato D’Auria,
  • Giulio Mengozzi,
  • Gianfranco Politano,
  • Salvatore Oliviero,
  • Nadia Raffaelli,
  • Silvia Deaglio

DOI
https://doi.org/10.1038/s41467-019-12055-2
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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The enzyme nicotinate phosphoribosyltransferase (NAPRT) mediates the rate-limiting step in NAD salvage pathway starting from nicotinic acid. Here the authors show that NAPRT can be detected extracellularly, binds to Toll like receptor 4, and activates NF-kB signaling and cytokine production in macrophage via NAD synthesis-independent pathways.