The gut microbiome and metabolome in kidney transplant recipients with normal and moderately decreased kidney function

Yang Lan; Duo Wang; Jiayang He; Hongji Yang; Yifu Hou; Wenjia Di; Hailian Wang; Xiangwei Luo; Liang Wei

doi:10.1080/0886022X.2023.2228419

Renal Failure (Dec 2023)

The gut microbiome and metabolome in kidney transplant recipients with normal and moderately decreased kidney function

Yang Lan,
Duo Wang,
Jiayang He,
Hongji Yang,
Yifu Hou,
Wenjia Di,
Hailian Wang,
Xiangwei Luo,
Liang Wei

Affiliations

Yang Lan: Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province and Institute of Organ Transplantation, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
Duo Wang: Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province and Institute of Organ Transplantation, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
Jiayang He: Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province and Institute of Organ Transplantation, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
Hongji Yang: Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province and Institute of Organ Transplantation, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
Yifu Hou: Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province and Institute of Organ Transplantation, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
Wenjia Di: Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province and Institute of Organ Transplantation, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
Hailian Wang: Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province and Institute of Organ Transplantation, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
Xiangwei Luo: Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province and Institute of Organ Transplantation, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
Liang Wei: Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province and Institute of Organ Transplantation, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China

DOI: https://doi.org/10.1080/0886022X.2023.2228419
Journal volume & issue: Vol. 45, no. 1

Abstract

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AbstractBackground The kidney transplant recipients (KTRs) were diagnosed with Chronic Kidney Disease after transplantation (CKD-T). CKD-T can be affected by the microbial composition and metabolites. The present study integrates the analysis of gut microbiome and metabolites to further identify the characteristics of CKD-T.Methods We collected 100 fecal samples of KTRs and divided them into two groups according to the stage progression of CKD-T. Among them, 55 samples were analyzed by Hiseq sequencing, and 100 samples were used for non-targeted metabolomics analysis. The gut microbiome and metabolomics of KTRs were comprehensively characterized.Results As well as significant differences in gut microbiome diversity between the CKD G1-2T group and CKD G3T group. Eight flora including Akkermansia were found to be enriched in CKD G3T group. As compared with CKD G1-2T group, the relative abundance of some amino acid metabolism, glycerophospholipid metabolism, amino acid biosynthesis, carbohydrate metabolism and purine metabolism in CKD G3T group were differential expressed significantly. In addition, fecal metabolome analysis indicated that CKD G3T group had a unique metabolite distribution characteristic. Two differentially expressed metabolites, N-acetylornithine and 5-deoxy-5'-(Methylthio) Adenosine, were highly correlated with serum creatinine, eGFR and cystatin C. The enrichment of gut microbial function in CKD-T is correlated with the expression of gut metabolites.Conclusion Gut microbiome and metabolites in the progression of CKD-T display some unique distribution and expression characteristics. The composition of the gut microbiome and their metabolites appears to be different between patients with CKD G3T and those with CKD G1-2T.

Published in Renal Failure

ISSN: 0886-022X (Print); 1525-6049 (Online)
Publisher: Taylor & Francis Group
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the genitourinary system. Urology
Website: https://www.tandfonline.com/journals/irnf

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