Sarcoidosis: old certainties and new perspectives

Abstract

Introduction Sarcoidosis is the paradigm of the internistic disease. It virtually affects every organ and tissue and is characterized by the presence of noncaseating granulomas. A holistic view is needed for the diagnosis and treatment of the disease. The authors provide an overview on several recently published studies, which pose new perspectives on the approach to the disease.Materials and methods The authors reviewed the scientific literature focusing on new etiopathogenetic, diagnostic and therapeutic data.Results and discussion A multimodal approach is appropriate and effective in the diagnosis and treatment of systemic diseases such as sarcoidosis. In this context, the internist plays a key role more than any other specialist.

Keywords

• Sarcoidosis
• HLA antigens
• Granuloma
• Peptidyl-dipeptidase A
• Adalimumab