Frontiers in Neuroscience (May 2013)

Adaptive Cluster Analysis Approach for Functional Localization Using Magnetoencephalography

  • Hooman eAlikhanian,
  • Hooman eAlikhanian,
  • J. Douglas eCrawford,
  • J. Douglas eCrawford,
  • Joseph F X DeSouza,
  • Joseph F X DeSouza,
  • Douglas eCheyne,
  • Gunnar eBlohm,
  • Gunnar eBlohm

DOI
https://doi.org/10.3389/fnins.2013.00073
Journal volume & issue
Vol. 7

Abstract

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In this paper we propose an agglomerative hierarchical clustering Ward’s algorithm in tandem with the Affinity Propagation algorithm to reliably localize active brain regions from magnetorencephalography (MEG) brain signals. Reliable localization of brain areas with MEG has been difficult due to variations in signal strength, and the spatial extend of the reconstructed activity. The proposed approach to resolve this difficulty is based on adaptive clustering on reconstructed beamformer images to find locations that are consistently active across different participants and experimental conditions with high spatial resolution. Using data from a human reaching task, we show that the method allows more accurate and reliable localization from MEG data alone without using functional magnetic resonance imaging (fMRI) or any other imaging techniques.

Keywords