Systemic Tumors Can Cause Molecular Changes in the Hippocampus That May Have an Impact on Behavior after Chronic Social Stress
Olatz Goñi-Balentziaga,
Alina Díez-Solinska,
Garikoitz Beitia-Oyarzabal,
Maider Muñoz-Culla,
Garikoitz Azkona,
Oscar Vegas
Affiliations
Olatz Goñi-Balentziaga
Department of Clinical and Health Psychology, and Research Methods, School of Psychology, University of the Basque Country (UPV/EHU), 20018 Donostia-San Sebastian, Spain
Alina Díez-Solinska
Department of Basic Psychological Processes and Their Development, University of the Basque Country (UPV/EHU), 20018 Donostia-San Sebastian, Spain
Garikoitz Beitia-Oyarzabal
Department of Basic Psychological Processes and Their Development, University of the Basque Country (UPV/EHU), 20018 Donostia-San Sebastian, Spain
Maider Muñoz-Culla
Department of Basic Psychological Processes and Their Development, University of the Basque Country (UPV/EHU), 20018 Donostia-San Sebastian, Spain
Garikoitz Azkona
Department of Basic Psychological Processes and Their Development, University of the Basque Country (UPV/EHU), 20018 Donostia-San Sebastian, Spain
Oscar Vegas
Department of Basic Psychological Processes and Their Development, University of the Basque Country (UPV/EHU), 20018 Donostia-San Sebastian, Spain
Evidence indicates that chronic social stress plays a significant role in the development of cancer and depression. Although their association is recognized, the precise physiological mechanism remains unknown. In our previous work, we observed that OF1 males subjected to chronic social defiance exhibited anhedonia, and those who developed tumors in the lung showed anxiety-associated behaviors. In this study, we observed that tumor-bearing OF1 mice presented higher levels of 3-HK, and this increase may be due to IDO. No differences in hippocampal catecholamine levels were observed. Our results suggest that a systemic tumor can induce molecular changes in the hippocampal kynurenine pathway that may impact behavior.
